Hon Stephen Kalonzo Musyoka was born on December 24,1953 in Tseikuru, Kitui County.

He is a lawyer by profession and holds a Post Graduate Diploma (PGD) in Business Management from Mediterranean Institute of Management, Nicosia, Cyprus; Diploma in Law from Kenya School of Law; Bachelor of Law from the University of Nairobi.

Kalonzo Musyoka won the Kitui North By-elections in 1985 and was appointed an Assistant Minister for Works, Housing, and Physical Planning. Re-elected MP in 1988 and elected Deputy Speaker of the National Assembly, Organizing Secretary of KANU, and member of KANU National Executive Committee.

In 1992, he has re-elected MP and appointed Minister for Foreign Affairs and International Cooperation.

He was re-elected in 1997 and appointed Minister for Education and Human Resources Development, Minister for Tourism and Information, Elected National Vice-Chairman of KANU, re-elected MP in 2002, and appointed Minister for Foreign Affairs.

Fast forward to 2008 Musyoka appointed  as Vice-President by Kibaki in January 2008 where he served till 2013.